Alain Borgeat

Alain Borgeat was clinically working as Head of the Anesthesiology Department, Balgrist University Hospital Zurich, Switzerland with the main focus on Regional Anesthesia and Perioperative Pain Medicine. Since his retirement he works as Senior Research Consultant at the Balgrist Campus, University of Zurich. He was chairman and initiator of the…

Nick Sutcliffe

Dr Nick Sutcliffe is a UK trained senior clinician with more than 30 years of experience in the fields of Medicine and Anaesthesia. His clinical interests include Intensive Care Medicine (ICM) and Total Intravenous Anaesthesia (TIVA). He is a recognised specialist in TIVA and regularly gives lectures and workshops, both…

Luc Barvais

Not surprisingly, Luc Barvais from the Erasme University in Bruxelles was the initiator of the development of a local Target Controlled Infusion (TCI) system.  He made a major contribution to the teaching of TCI with the very frequently cited and downloaded publication. We encourage you to take notice from this…

Frank Engbers

Until my retirement, just before the Covid pandemic, I was clinically working as a cardio-thoracic anaesthesiologist at the Leiden University Medical Centre with a special interest in paediatric anaesthesia for children with congenital heart disease(CHD). The interest in anaesthesia for CHD was certainly fuelled by the many CHD missions…

Pharmacokinetics DiY part 4 (effect compartment control)

The incentive of these pharmacokinetic DiY blogs was to give colleagues that have an interest in pharmacokinetics and pharmacodynamics a relative simple tool  to use published pk/pd models and make simulations that can be used to deepen the understanding of the tools like TCI that we use in daily…

Pharmacokinetics DiY part 3 (+Pharmacodynamics)

In part 1 I have explained how a relative simple spreadsheet can produce the concentration of an intravenous drug dose with given pharmacokinetic parameters that describe a 2 or 3 compartment model. In part 2, target controlled infusion(TCI)  for blood control has been introduced together with a method to…

Pharmocokinetics DiY part 2

In the pharmacokineticsDiY part 1 the numerical approach of pharmacokinetic calculations was explained. Using relative simple formulas implemented in a spreadsheet the concentrations of a drug could be calculated following variable drug input protocols. The Eleveld model for propofol was used. This was not without a reason. Douglas Eleveld and…

Pharmacokinetics DiY

part 1:building and verifying the spreadsheet This blog is about pharmacokinetics: Do It Yourself. Only a bit of knowledge of using spreadsheets is required. If you read publications on pharmacokinetics you will have noticed that the model parameters are usually presented in two different notations: clearances V1,V2,V3,…